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New Drug to Reduce Heart Muscle Damage After Heart Attack
Trials show that the drug, known as Dz13, specifically targets and neutralises the master regulator c-Jun gene, which is responsible for inflammation and muscle death in the aftermath of a heart attack.
The drug also reduces incidental cell and tissue death resulting from life-saving interventions such as balloon angioplasty and stent placements, or from the delivery of clot-busting drugs.
Significantly, the heart’s pumping action is protected by the drug, dramatically improving the patient’s chances of a full recovery after a heart attack.
“While this drug doesn’t prevent the heart attack, it does reduce the damaging effects of the blockage on the heart once it’s happened,” said lead investigator Professor Levon Khachigian, from the Centre for Vascular Research in the University of New South Wales.
“It’s a targeted therapy that can be used to complement other procedures and improve chances of a normal recovery,” he said.
Safety trials of Dz13 are now underway ahead of Phase 1 human trials. A paper outlining the animal study appears this month in the high-impact cardiovascular journal Arteriosclerosis, Thrombosis and Vascular Biology.
The heart muscle suffers damage at two distinct times during a heart attack, Professor Khachigian said: “first when the initial blockage occurs causing the chest pain, and second, when the patient undergoes an intervention, such as angioplasty or stenting, to reopen the blocked artery”.
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More News on: Drug Toxicity, Clinical Trials - Different Phases of the trial , Cardiac Risk or Risk of heart Attack, Cardiac Catheterization, Heart Attack, Diet Lifestyle and Heart Disease, Coronary Artery Bypass Grafting, Signature Drug Toxicity, Stress and the Gender Divide, Heart Attack Facts
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