New Discovery may Help Develop Drugs That Kill Cancer Cells

by Sreeraman on  December 27, 2009 at 7:37 AM Cancer News
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 New Discovery may Help Develop Drugs That Kill Cancer Cells
Scientists claim to have identified a family of "limpet-like" proteins that appears to play a vital role in repairing DNA damage which triggers cancer.

They hope that the finding may lead to new drugs, which could help kill cancer cells, and promote production of healthy replacements.

The Small Ubiquitin-like Modifier (SUMO) proteins appear to have a remarkable ability to zero in on the damaged areas.

They bind to normal proteins and direct them in to repair genetic glitches.

With this method, the proteins were even able to repair double strand DNA breaks - the most severe type of DNA damage.

And after the work is complete, the proteins detach themselves and move on.

The researchers focussed their study on BRCA1 gene, which, if damaged, is associated with a very high risk of breast cancer.

SUMO was shown to attach to the damaged gene, and switch it back on - helping prevent breast cancer forming.

"This new insight is the first step towards developing drugs which may protect normal cells from the side effects of chemotherapy, or improve the effectiveness of current breast cancer treatments," BBC News quoted Researcher Dr Jo Morris, from King's College London, as saying.

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