New Blood Biomarker Aids In Accurate And Early Detection Of Prostate Cancer

by Dr.Sunil Shroff on  February 28, 2008 at 5:28 PM Cancer News
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New Blood Biomarker Aids In Accurate And Early Detection Of Prostate Cancer
A new blood biomarker was identified by Researchers at the University of Texas Southwestern Medical Center, which accurately predicted the prostate cancer spread.

The finding can lead to more accurate prediction of cancer metastasis thereby improving patient management.

When cancer spreads beyond a solid tumor, it often does so at a microscopic level that typically cannot be identified by conventional imaging methods such as CT scans.

The new blood test measures levels of endoglin, a plasma biomarker that has been previously shown to predict the spread of colon and breast cancer.

In the study, the researchers said that endoglin could help predict whether a patient’s prostate cancer would spread beyond the solid tumor site into their lymph nodes.

“For prostate cancer, we have hit the limit of our ability to classify risk in these patients before initial surgery. We currently use prostate specific antigen, Gleason grade and a rectal exam, but the predictive value of those three tests is inadequate for predicting what cancers will spread. Conventional imaging modalities used for clinical staging in prostate cancer are inadequate to detect small but clinically significant lymph node metastases,” said Shahrokh F. Shariat, MD, chief urology resident at the University of Texas Southwestern Medical Center and study author.

“Although it is recognized that pelvic lymphadenectomy can provide important staging and prognostic information, it is still not clear in whom this procedure should be done. Doing pelvic lymphadenectomy on all patients is not universally practiced, as this procedure could be time consuming and is not without morbidity. As such, it would be of tremendous benefit to have an accurate blood marker that identifies patients in whom pelvic lymphadenectomy should be done,” said Claus G. Roehrborn, MD, professor, chairman of Urology at the University of Texas Southwestern Medical Center and co-author of the study.

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