A promising new approach for the treatment of symptoms of Parkinson's disease and other neurodegenerative diseases and disorders has been found by scientists at the University of California, San Francisco.
They used a novel cell-based strategy to treat motor symptoms in rats with a disease designed to mimic Parkinson's disease.
AdvertisementThe scientists transplanted embryonic neurons from foetal rats into an area of the adult rat brain known as the striatum, which integrates excitatory and inhibitory neurotransmitter signals to control movement.
In Parkinson's disease, cells that produce the neurotransmitter dopamine are damaged, and thus unable to project their communication wires, or axons, to the region.
As a result, the balance of excitation and inhibition in the striatum is lost, causing the motor deficits that are a primary symptom of the disease.
In the study, the transplanted embryonic neurons migrated and integrated into the correct neural circuitry of the striatum, matured into so-called GABAergic inhibitory interneurons, and dampened the over-excitation in the region.
The rats had improved motor function, as seen in their balance, speed, and length of stride during walking. Moreover, the healthy "control" rats in which the cells had been transplanted took longer strides and ran faster on a runway test.
The researchers say that the results demonstrate that the transplanted cells, known as embryonic medial ganglionic eminence (MGE) cells, can very precisely modify the balance of excitation and inhibition in neural circuits to influence behavior.
As overactive neural circuits are associated with other neurodegenerative diseases - a result of nonfunctioning or missing cells or abnormal synaptic transmission-the finding may have broad implications.
"This strategy represents a whole new approach to treating nervous system disorders," says neurologist Arnold Kriegstein, the senior author of the study and director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF.
The study appears in the journal Cell Stem Cell.
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