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New Antidepressants may be Developed from Protein Responsible for Brain Cells Growth

by Kathy Jones on  October 25, 2010 at 9:24 PM Research News   - G J E 4
A protein involved in the growth and development of brain cells could also play a role in depression and provide a possible target for antidepressants, a new study has said.
 New Antidepressants may be Developed from Protein  Responsible  for  Brain Cells Growth
New Antidepressants may be Developed from Protein Responsible for Brain Cells Growth
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Ron Duman and colleagues at Yale University compared post-mortem brain samples from 21 people who had been depressed and 18 people of the same age.

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The group looked for differences in gene expression by comparing levels of messenger RNA-the middle-man between gene and protein production-throughout the entire genome, reports New Scientist.

While Duman's team found several hundred differences, most striking were levels of mRNA for a particular protein, MKP-1, which inhibits a pathway involved in neural growth and development.

The brains of people with depression contained twice the amount of other people.

When the group over-expressed the gene for MKP-1 in the brains of healthy rats, the animals began to show signs of depression, which disappeared when treated with an antidepressant.

Source: ANI
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