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New Age HIV Prevention Possible With Nanotechnology?
After transferring the loaded nanoparticles into the vaginas of female mice engineered to produce EGFP, the team could easily see how well their 'medicine' worked by checking if the vaginal cells stopped fluorescing.
The nanoparticle-delivery system silenced fluorescence just as well as a traditional lipid delivery system.
But, the researchers found that the lipid-treated mice developed signs of vaginal irritation, whereas those given the nanoparticles did not.
The nanoparticles also did a good job of spreading siRNA around - deep into vaginal tissue and into the uterus - and released their cargo slowly over a month.
And now, Saltzman is testing his nanoparticles against the monkey version of HIV, and says it "looks good". But there's still a long way to go.
"The challenge is to show it works against disease," he said.
The study is published in Nature Materials.
Source-ANI
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