Neuron Mismatch Could Cause Pain in Fibromyalgia Patients

October 31, 2007 at 5:09 PM Research News
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Neuron Mismatch Could Cause Pain in Fibromyalgia Patients
Patients with fibromyalgia often suffer from unexplained pain and scientists suggest that it could be due to a mismatch between sensory and motor systems.

In a study published in the journal Rheumatology, researchers asked patients to look at a reflection of one arm whilst moving their other in a different direction, which was hidden behind the mirror.

This created a mismatch between what the brain sees via sensory input and what it feels through the motor system that controls movement.

Of the 29 patients involved in the study, 26 reported feeling a transient increase in pain, temperature change or heaviness in their hidden limb - all symptoms of a ‘flare up’ of their condition.

This suggests that a mismatch between sensory and motor neurons could be at the root of the fibromyalgia – a condition affecting one in 100 people in the UK at some stage of their lives.

“The chronic pain experienced by people with fibromyalgia is hard to understand because there are no obvious clinical signs that pain should be experienced,” said Dr Candy McCabe, one of the researchers involved in the University of Bath and Royal National Hospital for Rheumatic Diseases study.

“We have shown that by confusing the motor and sensory systems we can exacerbate the symptoms felt by people diagnosed with the condition.

“This adds to a growing body of evidence that many of the symptoms of this common disorder may be perpetuated, or even triggered, by this sensory-motor conflict.

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