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Neuro Disorders Protected by A protein molecule
September 17, 2007 at 8:14 PM
Mental Health News
The cerebral cortex is a complex structure with many important functions and a very unique architecture consisting of different cell types arranged in a specific order of layers. During embryonic development the cortical layers are generated by neuronal progenitor cells that migrate long distances before they settle down in a given layer. The spatial organisation in cell layers is essential to cortical functions. When the layer architecture is disturbed, like in the case of lissencephaly where entire layers are missing, the consequences are mental retardation, muscle spasms and seizures. The new study by a team of EMBL researchers reveals that a molecule called n-cofilin can play a key role in the disease.
We genetically engineered mice that lack n-cofilin and they show the same anatomical defects and symptoms as patients suffering from lissencephaly, says Walter Witke, whose team carried out the research. Their brains miss several cortical layers because neurons do not migrate normally during development.
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