New research, including an Indian-origin boffin, suggests that 'good cholesterol' (High-density lipoprotein) can act as a special delivery vehicle of destruction for cancer.
A research team, led by scientists from The University of Texas MD Anderson Cancer Center and the University of North Texas Health Science Center, found that synthetic HDL nanoparticles loaded with small interfering RNA to silence cancer-promoting genes selectively shrunk or destroyed ovarian cancer tumors in mice.
"RNA interference has great therapeutic potential but delivering it to cancer cells has been problematic," said Anil Sood, the study's senior author and MD Anderson's director of Ovarian Cancer Research and co-director of the Center for RNA Interference and Non-Coding RNA at MD Anderson.
"Combining siRNA with HDL provides an efficient way to get these molecules to their targets. This study has several important implications in the ability to fight certain cancers."
The study has been reported in the April edition of Neoplasia.