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Nanoparticles and Its Application in Anti-cancer Drug Delivery
October 25, 2007 at 7:22 PM
Drug News
To overcome this problem, Dutch researcher Cristianne Rijcken, formulated a nanoparticles which can enclose the anti-cancer drug into it and thereby act as a carrier.
The spherical structures can encapsulate various fat-soluble medicines. These nanoballs are highly promising carriers for the controlled release of anticancer drugs.
Anticancer drugs sometimes have very harmful side effects because they do not distinguish between tumours and healthy tissue.
However by encapsulating these drugs in nanoparticles, they can be more frequently delivered to the right tissue.
Since the nanoparticles are biodegradable by nature, the drug is only released once the particles break down, and this breakdown period can be adjusted by using different components for the nanostructures.
The researcher has revealed that the nanoparticles consist of polyethylene glycol (PEG) chains that are attached to recently developed components—lactic acid derivatives of polymethacrylamides. The new chains possess the unique combined property of biodegradability and heat sensitivity.
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