Nanodiamonds Offer Safer, Effective Drug Delivery System

October 14, 2007 at 2:26 PM Research News
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The researchers have also found that aggregated clusters of nanodiamonds can work as a shield to prevent normal cells from being killed by chemotherapy drug, and release the drug slowly only after it has reached its cellular target.

“The nanodiamond cluster provides a powerful release in a localized place -- an effective but less toxic delivery method,” said co-author Eric Pierstorff, a molecular biologist and post-doctoral fellow in Ho’s research group.

It has also been found that the clusters of nanodiamonds can carry nearly five times the amount of drug carried by conventional materials.

The solubility of nanodiamonds in water also gives it the edge over many of the emerging nanoparticles with regard to clinical purposes.

“Five years ago while working in Japan, I first encountered nanodiamonds and saw it was a very soluble material,” said materials scientist Houjin Huang, lead author of the paper and also a post-doctoral fellow in Ho’s group.

“Nanodiamonds are very special. They are extremely stable, and you can do a lot of chemistry on the surface, to further functionalize them for targeting purposes. In addition to functionality, they also offer safety -- the first priority to consider for clinical purposes. It’s very rare to have a nanomaterial that offers both,” Huang added.

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