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Mutation Risk for Breast Cancer Underestimated for Asian Women
Allison Kurian, MD, and her colleagues at the Stanford University School of Medicine were perplexed. Computer models designed to identify women who might have dangerous genetic mutations that increase their risk of breast and ovarian cancer worked well for white women. But they seemed to be less reliable for another ethnic group.
In the study, Allison Kurian, MD, used computer models designed to identify women who might have dangerous genetic mutations that increase their risk of breast and ovarian cancer
However, they were taken by surprise when they found that in a head-to-head comparison between whites and Asians, two of the most commonly used computer models failed in predicting the presence of mutations in almost half of the Asian women studied.
"We've been repeatedly surprised when Asian women who the models predicted would probably not have the mutations do in fact have them," said Kurian.
She added: "Doctors and patients should have a higher level of suspicion when using these prediction models in Asian women, because they under-predicted the true number of clinically important mutations. We may have to consider more subtle patterns of family cancer history when considering genetic testing in this ethnic group."
While it is believed that mutations in two genes - BRCA1 and BRCA2 are linked to the development of breast or ovarian cancer in carriers, it was found that, not every woman with a family history of cancer or who develops these cancers has these mutations.
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More News on: Women and Cancer, Breast Biopsy, Pagets disease of the breast, Mastitis, Cancer and Homeopathy, Breast Cancer Facts, Cancer Facts, Cancer, Breasts - Structures and Types, Breast Lumps
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