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Muscles Start Taking Up More Blood Sugar in Anticipation of Sweets
When mice were conditioned to expect the sweet taste of saccharin, it activated their orexin-MH-sympathetic nervous system to promote insulin-induced glucose uptake, they found. Mice that were allowed to taste and lick a glucose solution for a few consecutive days and were then treated with an orexin-receptor blocker showed higher blood sugar levels than those injected with saline.
"The most important finding is that hedonic feeding affects muscle glucose utilization and that orexin is involved in the regulation," Minokoshi said.
Orexin has been shown to stimulate feeding, he added, and in fact, they confirmed that mice lacking the orexin gene were less interested than normal mice in sweets. He concludes that orexin may be responsible for controlling and coordinating both feeding behavior and muscle glucose metabolism.
Source-ANI
RAS
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