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Home » Diabetes News

Muscles Start Taking Up More Blood Sugar in Anticipation of Sweets

by Rajshri on December 04, 2009 at 9:14 PM Diabetes News

Scientists have said that even the anticipation of bingeing on donuts, ice cream and chocolate truffle can cause your muscles to start taking up more blood sugar.

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According to researchers, who reported the study in the December issue of Cell Metabolism, a Cell Press publication, the message is delivered via neurons in the brain's hypothalamus containing the chemical known as orexin and the sympathetic nervous system.

Orexin neurons are known to switch on when we are motivated to eat or seek other rewards. They also play a role in active wakefulness.

"Our results show that good taste, a pleasant meal, and its expectation stimulate muscle glucose utilization and thereby decrease blood glucose level during feeding," said Yasuhiko Minokoshi of the National Institute for Physiological Sciences in Japan.

"Thus, blood glucose level after feeding is controlled by hedonic as well as homeostatic regulatory systems," the expert added.

Minokoshi's team earlier showed that the fat hormone leptin activates glucose uptake and fat burning in muscle. Those effects depend on signals from the hypothalamus, a brain region that is critical for maintaining energy balance.

"However, an important role of the brain is to control the internal environment in our body by responding to and by anticipating external stimuli," Minokoshi said. That led him to suspect that the brain might control glucose metabolism in muscle based on expectations, and orexin seemed a prime candidate to mediate such an effect.

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Muscles Start Taking Up More Blood Sugar in Anticipation of Sweets

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