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Muscle Regeneration in Damaged and Healthy Tissues may Be Induced by Cdk9-55
The researchers reported their findings, Cdk9-55: A New Player in Muscle Regeneration in the Journal of Cellular Physiology (http://www.ncbi.nlm.nih.gov/pubmed/18546201?dopt=Abstract).
Adult skeletal muscle tissue can regenerate in response to direct injury, neurological dysfunction and genetic defects. This healing process begins with an activation of muscle stem cells, known as satellite cells. Once activated, the satellite cells multiply and then differentiate into specific types of muscle fibers that eventually fuse to reconstitute muscle tissue.
The researchers discovered that cdk9-55, a variation of the gene cdk9, is induced specifically when satellite cells begin differentiation and is necessary for the genetic reprogramming required to complete the muscle tissue regeneration process.
By administering cdk9-55 or a protein encoded by a cdk9-55 gene directly to the muscle or on a resorbable material applied to injured or diseased muscle tissue or to an area missing muscle tissue, we can regenerate muscle, said lead researcher Cristina Giacinti, a researcher at the Sbarro Institute and the Department of Histology and Medical Embryology, University of Rome "Sapienza" in Rome, Italy.
Researchers also found that cdk9-55 can be used to increase muscle tissues in healthy tissue.
Source-ANI
SPH
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