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Multiple Sclerosis More Aggressive in Kids Than Adults

by Sreeraman on November 20, 2009 at 11:41 AM Child Health News

Multiple sclerosis diagnosed in childhood is more aggressive and causes more brain lesions than that detected in adulthood, according to magnetic resonance images (MRI) performed by University at Buffalo researchers.

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However, patients with pediatric-onset MS- which comprise up to 5 percent of total MS cases-develop disabilities at a slower pace than patients with adult-onset MS, the data showed.

"Patients with pediatric-onset MS have three times as many relapses annually, than patients with adult-onset disease, which suggests there is greater disease activity in this population," said Dr. Bianca Weinstock-Guttman.

"But surprisingly, the average time to reach the secondary progressive phase of the disease is longer in patients who develop MS in childhood than in adult onset MS. Reaching the next stage of disability is almost 10 years longer in pediatric-onset patients," she continued.

MS causes demyelination- destruction of the sheath that protects and insulates nerve fibers. Breaks in the myelin sheath disrupt the flow of electrical impulses, causing loss of sensation and coordination.

The UB study involved four sets of patients-17 children with an average age of 13.7 who were diagnosed with MS 2.7 years earlier; 33 adults with an average age of 36.5 years who were diagnosed with pediatric MS 20 years earlier; 81 adults with an average age of 40 who have had MS for an average of 2.6 years; 300 adults with an average age of 50.5 who've had MS for 20 years.

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