A new three-drug combination can effectively treat patients newly diagnosed with multiple myeloma, say researchers from Dana-Farber Cancer Institute. Multiple myeloma is a cancer of white blood cells in the bone marrow.
The three-drug combination has shown in a phase 1/2 clinical trial that it is a 'highly effective regimen' in the treatment of this form of cancer.
Paul G. Richardson, of Dana-Farber, who led the study, said that partial responses or better were seen in all of the 66 patients treated with the drug combination in the multi-center study, with 74 percent having a "very good partial response rate" in the phase 2 population.
The rate of complete or "near complete" responses to the therapy was also encouraging at 54 percent.
The regimen, known as RVD, combined the drugs Revlimid (lenalidomide), Velcade (bortezomib) and dexamethasone, which previously were found to be highly effective in multiple myeloma patients who had relapsed or no longer responded to first-line therapies.
Fifteen of the 35 newly diagnosed patients in the open-label phase 2 portion of the study subsequently underwent autologous (using their own blood-forming stem cells) transplants, a standard treatment for multiple myeloma "and did very well," Richardson said.
For the entire group, after a median 19.3 months of follow up, the median time-to-progression (TTP) of the disease, progression-free survival (PFS), and overall survival (OS) had not yet been reached, according to the presentation.
The estimated TTP and PFS at one year are 76 percent, and the estimated one-year overall survival is 100 percent, the results showed.
Richardson says it was 'particularly exciting' to observe that the high response rate was not affected by the specific genetic characteristics of the patients' disease.
Patients with so-called "adverse cytogenetics" are at higher risk for treatment failure and death, but in the current study the drug combination worked as well for them as it did in patients with more favorable cytogenesis features.
Richard said that the toxic side effects of the treatment were 'manageable.'
"Our conclusion is that this is a highly effective regimen for newly diagnosed multiple myeloma patients. The combination has now gone into large phase 3 clinical trials, and we think it has the potential to be a new standard of treatment in multiple myeloma, " Richardson said.
The results have been described in an oral presentation at the American Society of Hematology's 51st annual meeting on Saturday, Dec. 5.