Mouse-Model Based Treatment For Kidney Disease

by Tanya on  September 04, 2009 at 8:23 AM Research News
  •   Print
  •   Share
  •   Comments
  •  Text 
X-linked nephrogenic diabetes insipidus (XNDI) is a severe congenital kidney disease caused by mutations in the V2R gene. Currently, there is no effective drug to specifically treat XNDI, mainly because there are no good animal models of the disease. However, Jürgen Wess and colleagues, at the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, have now developed a viable mouse model of XNDI that recapitulates the major manifestations of the human disease.

As analysis of the mouse model indicated that disease was associated with increased expression in the kidney of the protein EP4, the authors tested selective EP4 receptor agonists as potential therapeutics, and found that they alleviated all the symptoms of disease. The authors therefore suggest that selective EP4 receptor agonists could be of benefit to individuals with XNDI and hope that their mouse model can be used to test additional new therapeutic strategies.



Source-Eurekalert
TAN

 Email Email   RSS Feeds RSS Feeds   Print this page Print   Save this page Save   Link Link   Syndicate Syndicate   Comments Comments   Bookmark and Share
 
Comment & Contribute
Comments should be on the topic and should not be abusive. Comments are normally moderated and are reviewed after they are posted.
* Your comment can be maximum of 2500 characters

Notify me when reply is posted
I agree to the terms and conditions
  
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
X

Medwonders Health Network

  • Health News Index
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Archive
Date :
Category :
Keyword :
Quiz On Kidney
How healthy are your kidneys? To find out take part in our kidney quiz.
  • News Quick Links
News Central Health Watch
Latest Health News Health In Focus
News Category (500+) Breaking Health News
Popular News Celebrating Life
Health News and Press Release Medindia - Exclusive
News Photo Gallery India Special
News Video Gallery Lifestyle and Wellness
News From Other Resources
Kidney
Complete Medindia Resources
News Categories:  
Men's Health Center

Research Related News

» Overgrowth of Bacteria in Gut Blamed For Irritable Bowel Syndrome » New Drug That Only Attacks Cancer Cells Developed
» Personality Traits Linked To Longevity in Centenarians » Lack of Vitamin D in Diet Raises Stroke Risk in Japanese-Americans
» Why Bovine TB Continues to Spread Demystified in New Research » Seaweed Pill May Help Treat Arthritis
» P. Aeruginosa Infection Leads to Worse Outcomes and Increased Hospitalizations in COPD Patients » Hormone Boosts Production of Molecules Which Fight Skin Infection
Read More >>