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Mother's Milk Appears to Have Far-reaching Metabolic Consequences
"A key phenomenon required after birth is to adapt the body to a lower environmental temperature with respect to that experienced when the fetus is inside the mother's womb," said Francesc Villarroya of the University of Barcelona. "We find that a key inducer of heat production in neonates is FGF21, released by the liver in response to the initiation of suckling."
FGF21 (short for fibroblast growth factor 21) has recently emerged as a novel regulator of metabolism, Villarroya explained. Scientists knew that FGF21 is produced primarily in the liver, where it is induced after fasting in adult rodents and humans. FGF21 can also correct metabolic disorders of obese and diabetic mice.
In the new study, the researchers wanted to know whether FGF21 also has a role in metabolic shifts as newborn animals transition to life in the world. It appears that it does.
Plasma FGF21 levels and FGF21 gene expression in the liver rise dramatically after birth in mice, the researchers report. That increase is initiated by suckling and depends on the intake of lipid-rich milk. When the researchers mimicked the FGF21 postnatal rise by injecting FGF21 into fasting neonates, they found that the treatment enhanced the expression of genes involved in heat generation, or thermogenesis, within brown fat, to increase body temperature. Brown fat cells treated with FGF21 showed increased expression of thermogenesis genes. The cells also expended more energy and burned more glucose.
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More News on: Pasteurization of milk, Types of Milk, Why Do We Eat - Nutrition Facts, Diet Lifestyle and Heart Disease, Types of Food Allergies, The Magic Feeling of Being A Mother, The Acid-Alkaline balance, Diet and Health, Acid Base Dietary Balance and its Influence on Our Health and Wellbeing, Lactose Intolerance
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