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Mortality in Younger Postmenopausal Woman Reduced by HRT
For more than 60 years, HRT has been widely used to treat menopausal estrogen deficiency and may studies had reported that it was linked with a significant reduction in total mortality among younger postmenopausal women.
The available evidence also supported the routine use of HRT to increase longevity in postmenopausal women.
However, the 2002 publication of a major study, the Women's Health Initiative (WHI), indicated increased risk for certain outcomes in older women, without increasing mortality, which led to a debate regarding potential benefits or harm of HRT.
In an article researchers conducted a meta-analysis of the available data using Bayesian methods and concluded that HRT almost certainly decreases mortality in younger postmenopausal women.
Bayesian analysis uses prior data, updated with new information, to make statistical inferences.
The authors pooled results from 19 randomized trials that included age-specific data from the WHI, with 16,000 younger postmenopausal women (mean age 55 years) followed for 83,000 patient-years, and showed a mortality relative risk of 0.73.
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