Medindia

X

More on the Inner Workings of the Inflammatory Response to Leishmaniasis

by Rajshri on  March 13, 2010 at 7:59 PM Research News   - G J E 4
 More on the Inner Workings of the Inflammatory Response to Leishmaniasis
A study published March 12 in the open-access journal PLoS Pathogens has said that the secret world of inflammation is slowly being revealed by the application of advanced techniques in microscopy.
Advertisement

Researchers at the Hull York Medical School and the University of York used 2-photon microscopy to identify how killer T lymphocytes behaved when they enter sites of inflammation caused by the parasite Leishmania donovani, and which infected cells they were able to recognise.

Advertisement
Leishmaniasis is a globally important but neglected disease, affecting approximately two million people every year. For most people, infection results in a slow-to-heal skin ulcer. In others, however, the parasite targets the liver, spleen and bone marrow, leading to over 70,000 deaths annually.

The Leishmania parasite is eventually contained by a characteristic type of inflammatory response that forms cellular structures called 'granulomas'. Little is known about the inner workings of these granulomas, in spite of their occurrence in other human diseases, from tuberculosis to rheumatoid arthritis.

The York-based research team used an advanced laser-based microscopy technique, called '2-photon imaging', to view the inner workings of the granuloma in mice infected with Leishmania. This enabled them to study how killer lymphocytes, such as those that can be induced by vaccination, are able to enter into the granulomas, penetrate deep into the core of the structure and seek out specific types of parasite-infected cells.

Although this technique can not be used currently for the study of inflammatory disease in humans, the insights provided into the biology of granulomas and the hidden world of inflammation should help to improve vaccines and drugs, and allow researchers to now construct in silico models for this type of inflammatory process.



Source: Eurekalert
RAS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All

More News on: