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More on Body Mass Index and Thrombogenic Factors in Newly Menopausal Women

by Kathy Jones on August 29, 2010 at 11:42 AM Women Health News

Researchers are only beginning to understand how BMI affects the physiological processes involved in the development of cardiovascular disease in menopausal women.

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Now, a study of a subset of women in the Kronos Early Estrogen Prevention Study (KEEPS), suggests that as BMI increases, so do platelet reactivity and thrombogenic microvesicles and activated protein C in the blood�all of which contribute to the formation of atherothrombosis and associated cardiovascular events. Moreover, as BMI increases, so do traditional established cardiovascular risk factors such as blood pressure, blood glucose, total cholesterol, LDL cholesterol, triglycerides, and high-sensitive C-reactive protein.

Muthuvel Jayachandran, Assistant Professor of Physiology in the Mayo Clinic's Department of Physiology and Biomedical Engineering in Rochester, Minn., is the lead author of the study which is entitled, "Body Mass Index and Thrombogenic Factors in Newly Menopausal Women." He will present his team's findings at the 2010 American Physiological Society (APS) conference, Inflammation, Immunity, and Cardiovascular Disease, in Westminster Colorado, August 25-28. The full conference program can be found at http://www.the-aps.org/meetings/aps/inflammation/.

The Study

The Mayo researchers assessed cardiovascular risk factors in 118 women newly enrolled in the KEEPS, an ongoing multicenter study designed to evaluate the effectiveness of hormone replacement therapy in preventing cardiovascular disease in newly post-menopausal women aged 42 to 58. All women in the study had their final menstrual period less than 36 months prior to enrollment.

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