Molecular Pathway That Plays A Role In Diabetes-Associated Blindness Discovered

by Aruna on  November 28, 2009 at 11:23 AM Diabetes News
RSS Email Print This Page Comment
 Molecular Pathway That Plays A Role In Diabetes-Associated Blindness Discovered
The University of Oklahoma Health Sciences Center, Oklahoma City, scientists have identified a molecular pathway that appears to play a vital role in diabetes associated blindness.
Advertisement

Diabetic retinopathy, damage to the retina in the eye as a result of inflammatory complications of diabetes mellitus, affects up to 80pct of all patients who have had diabetes for 10 years or more.

Advertisement
The new discovery might help researchers in developing novel drugs to combat diabetic retinotherapy.

The team has discovered that the Wnt signaling pathway plays a role in diabetic retinopathy.

During the study, lead researcher Dr. Jian-xing Ma examined retinal expression and activation of a Wnt signaling molecule in human patients with diabetic retinopathy as well as in mouse models.

They found high retinal expression and activation of Wnt signaling molecules in patients with diabetic retinopathy.

However, blocking Wnt signaling decreased the severity of diabetic retinopathy in mouse models. Wnt therefore provides a new target for diabetic retinopathy therapy.

Dr. Ma and colleagues suggest that "Wnt pathway activation is a novel pathogenic mechanism for [diabetic retinopathy] in both human patients and in animal models. Thus, the Wnt pathway represents a new target for pharmaceutical intervention of [diabetic retinopathy]."

The study appears in The American Journal of Pathology.

Source: ANI
ARU
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Blindness Facts Best Disease Usher Syndrome 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive