New clinically meaningful electrocardiogram abnormalities were rare with the modafinil and placebo group.
Modafinil did not affect sleep architecture in any patient population according to polysomnography.
Clinically significant abnormalities in mean laboratory parameters were observed in less than one percent of patients in modafinil-treated patients at the final visit.
“Modafinil is well tolerated. Furthermore, it appears from these prospective research studies that daily modafinil administration confers a low risk of adverse events or severe adverse events. These results make for a positive risk-benefit ratio for using modafinil to treat excessive sleepiness in patients with shift work sleep disorder, OSA and narcolepsy,” said Dr. Roth.
The American Academy of Sleep Medicine (AASM) recommends that people who suspect that they might have a sleep disorder see a primary care physician or a sleep medicine specialist for proper diagnosis and to discuss treatment options before treatment with medications is undertaken.
While modern hypnotics are considered safe, individuals should be aware that, like all medications, side effects may occur in patients.
Sleep medications are effective and safe treatments when used properly and judiciously by a patient who is under the supervision of a sleep medicine or primary care physician.
Source-Eurekalert
GAN/V