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Miracle 'Exercise Pill' is a Myth: Experts
Recently, researchers at the Salk Institute for Biological Studies had published a study in the journal Cell on the results of a substance that increased exercise endurance without daily exertion when tested in mice.
Media reports have described this substance as an "exercise pill", potentially eliminating the need for exercise.
Now, Frank Booth, a University of Missouri expert on the science of inactivity, says the "exercise pill" study did not test all of the commonly known benefits of exercise and taking the pill cannot be considered a replacement for exercise.
In the Cell paper "Exercise Mimetics" the researchers demonstrated that AMPK-PPARd pathways, which is a cellular messenger system, can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise. However, Booth cautions that some of the commonly known benefits of exercise were not tested in the Cell paper including - decreased resting and submaximal exercise heart rate, increased heart stroke volume at all exercise work loads, increased maximal exercise cardiac output, lower blood pressure and arterial stiffness and increased aerobic capacity.
The prevention of the increased risk of chronic disease produced by lifelong physical inactivity also was not tested in the Cell paper.
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