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Micro-screening Devices for Drug Discovery in Offing
The study may be used for creating micro-screening devices for drug discovery and other such applications.
Bhagwati Gupta, assistant professor of biology, said: "This is the first time that worms have been stimulated to move in a micro-channel device in a very precise and directed way.
"It will allow researchers to study in real time how a proposed drug affects neurons and muscles that control motion of a live specimen."
Researchers showed the worms' movement forward and in reverse inside a microchannel as the organisms were guided by the direction of the electric field (electrotaxis).
Ravi Selvaganapathy, assistant professor of mechanical engineering, said: "The electrotaxis of the worms has the potential to automate what is currently a slow, manual process for drug screening on worms.
"The system is fairly easy and inexpensive to scale up to conduct rapid screening of tens of thousands of chemicals in worms to identify drug candidates in a cost-effective manner. Such discovery could accelerate clinical trials in people by allowing scientists to focus only on relevant drugs and would use limited resources more efficiently."
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More News on: Drug Toxicity, Clinical Trials, Clinical Trials - The Past and The Future , Clinical Trials - Different Phases of the trial , Signature Drug Toxicity
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