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Metabolism Of Protein Crucial To Lymphoma Growth Uncovered
August 31, 2007 at 7:43 PM
Genetics & Stem Cells News
"It appears that PAX5, which regulates gene expression, instructs B cells to make enough of the components of B cell receptors to spur tumor growth even in the absence of foreign antigens, which normally initiate the immune response," Thomas-Tikhonenko said.
Studies on human clinical samples corroborated this conclusion. Approximately half of lymphoma samples from the University of Oxford's John Radcliffe Hospital tumor bank exhibited evidence of abnormal B cell receptor activation.
The study was conducted by Thomas-Tikhonenko, Cozma, Duonan Yu and Anna Azvolinsky of Penn Vet's Department of Pathobiology; Suchita Hodawadekar and Michael Atchison of Penn Vet's Department of Animal Biology; Shannon Grande and John Monroe of the Department of Pathobiology and Laboratory Medicine in the Penn School of Medicine; John Tobias of the Biomedical Informatics Core at Penn; Michele Metzgar and Jan Erikson of the Wistar Institute; and Jennifer Paterson and Teresa Marafioti of the John Radcliffe Hospital.
The research was funded by the National Cancer Institute and the Commonwealth of Pennsylvania Health Research Formula Fund.
Source-Eurekalert
JAY/C
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