Medindia

X

Menthol Receptor-A Thermosensitivity Determinant in Cold Temperature

by Medindia Content Team on  June 8, 2007 at 10:28 AM General Health News   - G J E 4
Menthol Receptor-A Thermosensitivity Determinant in Cold Temperature
According to a study in Nature by Yale School of Medicine, the University of California at San Francisco (UCSF), and the University of Wisconsin, the menthol receptor detects a wide range of cold temperatures and relays the information to the brain.
Advertisement

The finding solves the mystery of how important the ion channel TRPM8 is for alerting the body to cold temperatures."TRPM8 is the primary, if not sole, determinant of thermosensitivity in the cool range," the researchers noted. "It also contributes to the detection of extreme cold, or temperatures below 15 C degrees."

Advertisement
Cold, heat, sound, light, taste, and smell are detected and converted into neural impulses through the activation of receptors, which then propagate the signal by opening an ion channel. Once the channel is open, an electrical impulse travels to other neurons.

In this paper, Sven-Eric Jordt, assistant professor of pharmacology at Yale, and colleagues, found that isolated, cultured nerve cells that express TRPM8 react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8.

"TRPM8 does not seem to be the sole receptor responsible for detecting cold," Jordt said. "The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold."

Source: Eurekalert
JAY/M
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All

More News on: