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Medicines Meant to Treat Alzheimers Found to be Good for Victims of Dementia
In the study, researchers from the Indiana University School of Medicine, the Regenstrief Institute and Wishard Health Services reviewed nine randomised, double-blind, placebo-controlled clinical trials.
The trials were meant to evaluate the effectiveness of three popular cholinesterase inhibitors in managing behavioural and psychological symptoms displayed by patients with Alzheimer's disease.
The results suggested that cholinesterase inhibitors led to a statistically significant reduction in behavioural and psychological symptoms such as aggression, wandering or paranoia when using the same dosage as administered for improving cognitive impairment.
It was found that nine out of 10 Alzheimer's disease patients display behavioural and psychological symptoms of their disease.
The review of the clinical trials revealed that cholinesterase inhibitors are safe, producing no major side effects.
"There is a need for safe alternatives to the anti-psychotic drugs currently used to manage the behavioural and psychological symptoms of Alzheimer's disease. The results of the studies we analysed are encouraging and suggestive that cholinesterase inhibitors are safe and effective alternatives. However, they are under-utilised and typically prescribed for less than three months and for less than 10 percent of patients with Alzheimer's disease. Our findings might provide clinicians with useful data to justify the appropriate use of these medications," said Malaz Boustani, M.D.
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