Crossing 2C null mice with mice that express Cre-recombinase in POMC neurons resulted in mice with 5-HT2CRs expressed only in POMC neurons (called 2C/POMC).
The researchers observed that 2C null mice, as expected, exhibited excessive eating, hyperactivity, and obesity and showed reduced responses to 5-HT drugs known to suppress appetite.
"Our unique genetic mouse models have revealed that POMC neurons are physiologically important targets of potent anorexigenic 5-HT compounds such as d-fenfluramine to suppress appetite," said Elmquist.
The research appears in journal Neuron.
Source-ANI
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