Male Infertility Gene Discovered

by Kathy Jones on  October 3, 2010 at 9:38 AM Genetics & Stem Cells News
RSS Email Print This Page Comment bookmark
Font : A-A+

The gene that causes infertility in men has been discovered by scientists from the Pasteur Institute in France and University College London.
 Male Infertility Gene Discovered
Male Infertility Gene Discovered

Mutations of the NR5A1 gene were found in a small percentage of infertile men. This gene is already known to be involved in sexual development in both men and women - it is been linked to physical defects in the development of the testicles or ovaries.

"Given the complexity of the sperm production process it is likely that many genes are involved," BBC quoted Dr Allan Pacey, as saying.

In a group of 315 apparently healthy men, the team found mutations in the gene in just seven, and closer examination revealed the men had altered levels of sex hormones and, in one case, mild abnormalities in the cellular structure of the testicles.

"We conclude that approximately 4pc of men with otherwise unexplained failure to produce sperm carry mutations in the NR5A1 gene," they concluded.

"Although this gene defect affects only a small number of men, we need more studies like this so that we can fill in the gaps in our knowledge and possibly one day build a robust diagnostic test for male fertility based on genetics," Pacey said.

The study is published in the American Journal of Human Genetics.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

DNA Finger Printing Genetic Counseling Genetics of Male Infertility In Vitro Fertilization (IVF) Infertility Vaginitis Egg Donation Artificial Insemination Polycystic Ovarian Syndrome Dilatation and Curettage 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive