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Malaria's Key Survival Protein Identified, Offers Drug Hope
Professor Cowman said experimentation had shown that the action of Plasmepsin V on the effector proteins was the first step in priming the proteins to be exported beyond the parasite's membrane into the red blood cell cytoplasm.
"Plasmepsin V is responsible for determining that all the hundreds of effector proteins are exported. If we could find drugs to block Plasmepsin V the malaria parasite would die," he said.
Professor Cowman said because Plasmepsin V was a protease it was an attractive drug target.
"Drugs that target proteases have been very effective in combating HIV so, by analogy, drugs that impede the function of Plasmepsin V should also show promise," he said.
Source-Eurekalert
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