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Malaria Mosquitoes Use Different Odour Sensors to Satisfy Bloodlust

by Tanya Thomas on September 02, 2010 at 11:44 AM Research News

Researchers at Vanderbilt University claim that the malaria mosquito apparently relies on a battery of different types of odour sensors to mediate its most critical behaviours, including how to choose and locate their blood-meal hosts.

Malaria Mosquitoes Use Different Odour Sensors to Satisfy Bloodlust

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In a new study, researchers have characterized two families of molecular odorant sensors in Anopheles gambiae, the mosquito responsible for the majority of human malaria transmission.

Intensive research on insect olfaction over the past decade has revealed many details of the cellular and molecular basis of odor recognition.

Considerable attention has been focused on a diverse family of odorant receptors (ORs) that are expressed throughout the antennae and other head appendages and which drive the responses to a variety of volatiles.

Combining gene-silencing techniques with a new behavioural assay, the study confirms that one of the modes of action of DEET, the most commonly used commercial insect repellent, is based on the activation of a specific OR family member.

However, ORs alone do not appear to be able to account for the breadth of mosquito olfactory sensitivity as several potentially important human-derived odors such as ammonia, butylamine and lactic acid, have consistently failed to activate mosquito ORs.

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Malaria Mosquitoes Use Different Odour Sensors to Satisfy Bloodlust

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