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Malaria Fight Gets a Significant Boost
They have successfully transplanted most of the 'nose' of the mosquito that spreads malaria into frog eggs and fruit flies.
The mosquito's 'nose' is centered in its antennae, which are filled with nerve cells covered with special 'odorant receptors' that react to different chemical compounds.
"We've successfully expressed about 80 percent of the Anopheles mosquito's odorant receptors in frog's eggs and in the fruit fly antennae," said Laurence Zwiebel, professor of biological ciences at Vanderbilt, whose lab performed the frog egg transplantation.
Previously, scientists have used frog eggs to study the olfactory receptors of moths, honeybees and fruit flies. DNA that encodes insect receptors are injected into a frog egg and given sufficient time to produce and localize proteins. As a result, the surface of the egg is covered with the mosquito odorant receptors.
An engineered egg is placed in a voltage clamp system and an odorant is dissolved in the buffer solution in which the egg is floating. If the mosquito receptors react to the compound, the electrical properties of the egg change in a measurable fashion.
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 | Quiz on Malaria Malaria is a common parasitic disease of the tropics, resulting in million deaths every year. Early detection and adequate treatment at the right time can reduce deaths due to malaria. Test your knowledge on this condition by taking this quiz. 
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