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MRSA Infections in Hospital ICUs can Be Lowered by 'Antibiotic Cycling'
The researchers said that the MRSA infection rate decreased from 1.9 to 1.4 patients per 100 admissions in the surgical ICU when they switched between two antibiotics, linezolid and vancomycin, every three months.
In their study report, published in the journal Surgical Infections, the researchers have also revealed that in-hospital mortality from surgical ICU-acquired MRSA infections fell from 3.8 patients per year to none.
The report suggests that study data spanned six years, including the period before cycling began (1997 to 2001) and the period after it was instituted (2002 to 2003).
It also reveals that the study's key focus was resistant gram-positive cocci, a subgroup defined as MRSA (methicillin-resistant Staphylococcus aureus) and VRE (vancomycin-resistant Enterococcus).
"Before we began cycling, 67 percent of the Staphylococcus aureus infections in our surgical ICU were caused by MRSA. Cycling reduced MRSA cases to 36 percent of that total," says the lead author of the study, Dr. Robert Sawyer, a professor of surgery and co-director of UVA's Surgical Trauma Intensive Care Unit.
The researchers claim that their study is the first to assess the impact of antibiotic cycling on a group of bacteria known as gram-positive cocci.
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