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MRC Scientists Reveal Progress in Understanding Body's Natural Defenses

by Rajshri on  March 13, 2010 at 7:18 PM Research News   - G J E 4
 MRC Scientists Reveal Progress in Understanding Body's Natural Defenses
A new advance in understanding how the body fights certain types of cancer and other disease such as Lupus and rheumatoid arthritis has been made by Medical Research Council (MRC) scientists at the University of Leicester.
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Their findings have been published in the journal Nature Immunology. http://www.nature.com/ni/index.html The work has been carried out by a team at the MRC Toxicology Unit at the University of Leicester.

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Dr Melania Capasso, one of the authors of the study, described the findings as being 'very significant'.

"We showed that a newly discovered protein, HVCN1, regulates antibody production through modulation of intracellular oxidation. In the absence of HVCN1, the immune response is blunted. These findings are very novel and significantly contribute to our understanding of how the organism mounts an immune response.

"The findings are very significant for the immunology field and help elucidate the contribution of natural oxidants such as reactive oxygen species to B cell activation and represent the rationale for using HVCN1 as a target for therapies where activation of B cell needs to be diminished."

Dr Capasso said the findings could be useful for the treatment of some types of B cell lymphoma and the treatment of autoimmune diseases such as Lupus (and rheumatoid arthritis.



Source: Eurekalert
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