Sentinel lymph node biopsy (SNLB) procedure shows positive results in patients with Merkel Cell Carcinoma. Merkel Cell Carcinoma patients who underwent this procedure had a lower risk of cancer recurrence after two years, reveals study by Fox Chase Cancer Center researchers. When the biopsy's results were used to guide subsequent tests and treatment, these patients had longer survival rates than patients who had not undergone the procedure.
"Sentinel lymph node biopsy, or SNLB, can be used to recommend which way to proceed with a patient's treatment," says Aruna Turaka, M.D., a radiation oncologist at Fox Chase and lead author on the new study. Turaka will present her team's findings at the 53rd Annual Meeting of the American Association for Radiation Oncology on Monday, October 3.
"Right now, with almost all patients, even stage I patients, we recommend radiation to the local site. But this study can help us make more judicious use of treatment and identify who will be most benefited to the regional lymph nodes," Turaka says.
Merkel cell carcinoma is a rare and aggressive type of skin cancer that forms in cells at the bottom of the epidermis, usually striking older people and people with weakened immune systems. The tumor often appears as a painless, fast-growing lump on a part of the body exposed to the sun, including the head and neck, the trunk, and legs and arms. The cancer is believed to metastasize from an early stage, first spreading to nearby regional lymph nodes. It may spread to other lymph nodes, as well as the lungs and other organs. The first lymph node where cancer cells appear is called the sentinel lymph node.