Lung Regeneration Comes Closer to Reality

by Sheela Philomena on  October 31, 2011 at 3:35 PM Respiratory Disease News   - G J E 4
Lung regeneration - an advance to treat millions of people suffering from respiratory disorders could soon be a reality, thanks to the discovery by researchers at Weill Cornell Medical College.
 Lung Regeneration Comes Closer to Reality
Lung Regeneration Comes Closer to Reality

The research team said that they have uncovered the biochemical signals in mice that trigger generation of new lung alveoli, the numerous, tiny, grape-like sacs within the lung where oxygen exchange takes place.

Specifically, the regenerative signals originate from the specialized endothelial cells that line the interior of blood vessels in the lung.

While it has long been known that mice can regenerate and expand the capacity of one lung if the other is missing, this study now identifies molecular triggers behind this process, and the researchers believe these findings are relevant to humans.

"Several adult human organs have the potential upon injury to regenerate to a degree, and while we can readily monitor the pathways involved in the regeneration of liver and bone marrow, it is much more cumbersome to study the regeneration of other adult organs, such as the lung and heart," said the study's lead investigator Dr. Shahin Rafii.

"It is speculated, but not proven, that humans have the potential to regenerate their lung alveoli until they can't anymore, due to smoking, cancer, or other extensive chronic damage.

"Our hope is to take these findings into the clinic and see if we can induce lung regeneration in patients who need it, such as those with chronic obstructive pulmonary disease (COPD)," added Dr. Rafii, who is the Arthur B. Belfer Professor of Genetic Medicine and co-director of the Ansary Stem Cell Institute at Weill Cornell Medical College.

The study appeared in the Oct. 28 issue of the journal Cell.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All

More News on: