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Liver in Mice Prevented from Ageing: Study
This is the first time that age-related decline due to protein build-up has been arrested in an entire organ or in a live animal, it said.
The findings could pave the way to therapies for life-threatening liver conditions common in the late stages of life, the study said.
They could even lead to a recipe for boosting longevity.
In experiments, livers in genetically modified mice 22-to-26 months old -- the equivalent of octogenarians in human years -- cleaned blood as efficiently as those in animals a quarter their age.
By contrast, the livers of normal mice in a control group began to fail.
The benefits of restoring the cleaning mechanisms found inside all cells could extend far beyond a single organ, said the study's main architect Ana Maria Cuervo, a researcher at the Albert Einstein College of Medicine at Yeshiva University in New York City.
"Our findings are particularly relevant for neurodegenerative disorders such as Parkinson's and Alzheimer's," she told AFP.
"Many of these diseases are due to 'misbehaving' or damaged proteins that accumulate in neurons. By preventing this decline in protein clearance, we may be able to keep these people free of symptoms for a longer time," she explained in a e-mail.
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