login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Liver Transplantation Linked to Accelerated Cellular Aging
Full details appear in the May issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases (AASLD).
The University of Cambridge research team investigated whether the chronic immune stress of liver disease and organ transplantation accelerates aging of the immune system, which in turn contributes to excess morbidity and mortality in established liver graft recipients. Study leader Dr. Graeme Alexander explains, "There is a marked increase in the prevalence of cardiac disease, malignancy, cerebrovascular disease and infections in patients with established liver grafts, affecting a majority of cases eventually and which in the past have been attributed to agents used to suppress immune responses. However, an alternative (and not exclusive) hypothesis is that liver transplant recipients develop premature immune senescence which is also associated with these same pathologies, perhaps consequent to chronic alloantigenic stimulation."
The study participants included 97 liver transplant recipients with established grafts (at least 3 years) and 41 age and sex-matched controls. When cases were compared with controls for each marker of immune senescence, the researchers discovered that liver graft recipients had shorter T-cell telomeres and more cells of a mature phenotype than healthy age-matched controls. Telomeres are chromosomal structures that shorten each time a cell divides. Scientists theorize that telomeres eventually become so short that they stop functioning, which causes the cell to stop proliferating. T-cells are lymphocytes, major players of the immune system. With age, these cells become less active, making the body more vulnerable. These cells are the focus of much research on the aging immune system.
|
|
|
More News on: Alcoholic Liver Disease, Hepatitis A, Liver Transplantation, Ageing and Sleep, Liver, Wilson's Disease, Bile Duct Cancer, Sclerosing Cholangitis, Hepatitis C, Transplantation
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
 | Quiz on Liver Did u know that the liver is about the size of an American football? Find out more from our liver quiz. 
|
- News Quick Links
 | News Central | | Health Watch | |
| Latest Health News | | Health In Focus | |
| News Category (500+) | | Breaking Health News | |
| Popular News | | Celebrating Life | |
| Health News and Press Release | | Medindia - Exclusive | |
| News Photo Gallery | | India Special | |
| News Video Gallery | | Lifestyle and Wellness | |
| News From Other Resources | |||
 |
Transplantation
Complete Medindia Resources
|
| News Categories: |
| » | Individuals' Brains 'Tick Together' If They Have Strong Emotions |
| » | Keeping Emotions in Check and Being Resilient Helps to Remain Satisfied With Life |
| » | Moral Sense Depends on Type of Activity Being Done at Particular Time |
| » | 'No Scanty Garbs' Campaign UAE Women |
| » | Asian Casinos Combat Crooks |
| More Life Style News | |
|
Organ Donation Related News |
||||||||
| » | Five People in China Lead Better Lives After Receiving Organs from a Brain Dead Boy | » | Germany Aims To Increase Organ Donations With New Reforms | |||||
| » | World’s Smallest Artificial Heart Implanted in 16-Month-Old Baby | » | Infections May Be Lethal For Kidney Failure Patients | |||||
| » | Delhi’s First Heart Transplant Recipient Leads a Normal Life | » | Social Networks Could be an Effective Means to Seek Organ Donation | |||||
| » | Combo Antibiotic Therapy Does Not Lower Organ Failure Risk In Sepsis Patients | » | Oldest Living Kidney Donor in Britain at 83 Years | |||||
| Read More >> | ||||||||
