Liver Transplant Patients may be Helped by Hepatitis C Treatment

by Rajshri on  November 04, 2009 at 8:38 PM Organ Donation News
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Extending hepatitis C treatment for liver transplant patients results in high rates of clearance of the hepatitis C virus from the blood, as well as a low rate of relapse, a study by doctors at Henry Ford Hospital has shown.

"We found that patients who achieved a sustained virological response were more likely to have had extended treatment. In addition, prolonging treatment for 52 weeks after patients were virus negative, resulted in a relapse rate of only 8 percent," said Kimberly Brown, Division head of Gastroenterology at Henry Ford Hospital and senior author of the study.

This is in contrast to typical relapse rates of 30-35 percent in non-transplant patients treated with standard therapy.

The study looked at 241 consecutive liver transplant patients from 1999-2006. Patients were offered treatment if they tested positive hepatitis C, had recurrent hepatitis C with at least Stage I fibrosis on biopsy, and stable immunosuppression for a minimum of three months.

Patients received either non-pegylated interferon tiw or pegylated interferon weekly in combination with ribavirin.

Of the study patients with hepatitis C, 66 were eligible for treatment, and 22 achieved sustained virological response. Only two patients (8 percent) relapsed.

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