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Liver Disease Treatments from a 'Humanized' Mouse

by Savitha C Muppala on  February 24, 2010 at 11:00 PM Research News   - G J E 4
 Liver Disease Treatments from a 'Humanized' Mouse
Scientists have generated a mouse with an almost complete human liver.
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The team, led by Salk Institute researchers, says this 'humanized' mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria.

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"We found that, not only can we infect our humanized mouse with Hepatitis B and Hepatitis C, but we can then successfully treat this infection using typical drugs," said first author Karl-Dimiter Bissig, an internist and post-doctoral researcher in the Laboratory of Genetics.

"As a physician, I understand the importance of this type of bench-to-bedside research. This study shows a real application for our mouse model, making it relevant from both an academic and a clinical perspective," Bissig added.

The findings will be published in the Feb. 22, 2010 online edition of the Journal of Clinical Investigation. (ANI)

Source: ANI
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