Link Between Stomach Hormone and Alcohol Addiction Laid Bare

A recent discovery regarding addictions like alcohol dependence may lead to improved therapies for the same. Scientists have identified a brain mechanism linked with l addiction and the stomach hormone ghrelin.

The researchers at the Sahlgrenska Academy, Gothenburg, have observed that blocking ghrelin's actions in the brain can reduce alcohol's effects on the reward system.

Britain Heading Towards Increasing Alcohol Dependence
A new British survey has revealed that almost one in 10 men, and one in 25 women, shows signs of alcohol dependence.

Ghrelin is a hormone produced by the stomach and, by signalling in the brain, it increases hunger.

Its involvement in alcohol addiction highlights the reward system of the brain as a key target for ghrelin's effects.

"Ghrelin's actions in the brain may be of importance for all kinds of addictions, including chemical drugs such as alcohol and even food," said Suzanne Dickson, Professor of Physiology, a leading expert in appetite regulation.

Negative Mood-Related Drinking Can Lead to Major Depression, Alcohol Dependence
A study has shown that negative mood-related drinking can make people vulnerable to developing both Major depression (MD) and alcohol dependence (AD).

The researchers showed that mice treated with ghrelin increase their alcohol consumption.

When ghrelin's actions are blocked, for example, by administering ghrelin receptor antagonists, mice no longer show preference for an alcohol-associated environment.

High Novelty-seeking and Low Avoidance of Harm Contribute to Alcohol Dependence
Individuals with the inactive form of aldehyde dehydrogenase-2 (ALDH2) normally don't drink alcohol because it causes flushing, nausea, and headaches.

This means that alcohol is no longer able to produce its addictive effects that include reward-searching behaviour (similar to craving in alcoholic patients).

"If we can develop drugs that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacological treatment will reach the patient", said a co-author of the study.

Alcohol Dependence and Binge-eating Heightened by the Peptide �ghrelin�
Ghrelin is known to have an effect on food intake by increasing feelings of hunger and the urge to eat.

Alcohol dependence is a complex and chronic disease that leads to adverse consequences affecting not only the patient but also their immediate family, and it also has a profound economic burden on society.

The results of the study will be published in the renowned American scientific journal Proceedings of the National Academy of Sciences (PNAS).

Source-ANI
TAN