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Leukemia Treatment may Improve with Gene Mutation Discovery
Patients with the gene mutation lived for a median of just over one year, while those without it lived for a median of three and a half years, according to the study in the November 11 issue of the New England Journal of Medicine.
Researchers made the discovery after sequencing the entire genome of a patient who had died from acute myeloid leukemia (AML), which kills around 9,000 Americans each year.
They then compared the patient's genome with 300 other patient samples and found that mutations in a single gene, called DNA methyltransferase 3A or DNMT3A, seemed to be responsible for treatment failure in many of the patients.
"Based on what we found, if a patient has a DNMT3A mutation, it looks like you're going to want to treat very aggressively, perhaps go straight to bone marrow transplantation or a more intensive chemotherapy regimen," said senior study author Richard Wilson of Washington University's Genome Center.
Researchers found the gene mutation in about a third of patients studied and those whose prognosis based on existing tests was uncertain, or viewed as an "intermediate" risk of treatment failure.
More than half of all such AML patients are typically treated with standard regimens of chemotherapy, which researchers said they now believe may not be the best approach.
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More News on: DNA Finger Printing, Leukemia, Chronic Myeloid Leukemia, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Multiple Myeloma, Von Recklinghausen's Disease, Bone Marrow Transplantation
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