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Leak in Muscle Cells Lead to Fatigue in Athletes
February 12, 2008 at 3:50 PM
Research News
According to the study, the fatigue that marathoners and other extreme athletes feel at the end of a race is caused by a tiny leak inside their muscles that probably also saps the energy from patients with heart failure.
The leak, which allows calcium to continuously leak inside muscle cells, weakens the force produced by the muscle and also turns on a protein-digesting enzyme that damages the muscle fibers.
The study, conducted by senior author, Andrew Marks, M.D., chair of the Department of Physiology and Cellular Biophysics, and director of the Clyde and Helen Wu Center for Molecular Cardiology at Columbia University Medical Center and colleagues, found that the leak was present in the muscle of mice after an intense three-week daily swimming regimen and in human athletes after three days of daily intense cycling.
Marks and colleagues have found the same leak previously in the muscles of animals with heart failure.
The study does not mean exercise is bad for you. We only saw the leak in animals and human athletes that exercised three hours a day at very high intensities for several days or weeks in a row until they were exhausted, Marks said.
He also noted that athletes muscles return to normal after several days of rest and any muscle damage will be repaired after several days or weeks depending on the degree of exercise.
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