Medindia

X

Langerhans Cells Elevate HIV Risk in STD Affected Persons: Study

by VR Sreeraman on  September 7, 2008 at 10:55 AM AIDS/HIV News   - G J E 4
Langerhans Cells Elevate HIV Risk in STD Affected Persons: Study
The Netherlands-based scientists have for the first time described a way whereby sexually transmitted diseases - such as genital herpes, gonorrhea, syphilis, and chlamydia - increases an individual's risk of becoming infected with HIV through sexual contact.
Advertisement

Teunis B.H. Geijtenbeek and colleagues at VU University Medical Center showed the way in which STDs can increase acquisition of HIV-1 infection in an ex vivo human skin explant model.

Advertisement
The researchers say that though immature immune cells known as Langerhans cells (LCs) captured HIV in the ex vivo human skin explant model, they did not efficiently transmit the virus to T cells, something that is essential for the initiation of full disease.

However, when the cells were activated by inflammatory stimuli, efficient virus transmission was observed.

Based on this observation, the researchers came to the conclusion that the triggering of the same inflammatory stimuli in vaginal and skin explants by agents that cause the STDs may activate LCs, and thereby increase an individual's risk of becoming infected with HIV.

The researchers say that their study also suggests that anti-inflammatory therapies may provide a way to prevent HIV transmission.

Source: ANI
SRM
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All