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Lack of Protein That Plays Pivotal Role in Male Infertility Identified | |
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In the study, male mice were found to have a low sperm count, with the remaining sperm looking abnormal (they had round heads) and being severely impaired in their ability to move. Further analysis revealed that compartments in the sperm known as acrosomes, which contain proteins that breakdown the outer membrane of the egg so that a sperm can enter for fertilization to occur, were malformed.
As PICK1 was shown to interact with two proteins (GOPC and CK2-alpha') in the vicinity of cellular structures that form acrosomes, the authors suggest that PICK1 has an essential role in acrosome formation.
Source-Eurekalert
SRM
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More News on: Genetic Counseling, Genetics of Male Infertility, In Vitro Fertilization (IVF), Infertility, Vaginitis, Egg Donation, Artificial Insemination , Polycystic Ovarian Syndrome, Dilatation and Curettage, Protein Catabolic Rate
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