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Lab Grown Transplantable Tissue Encourages Nerve Regeneration
Dr. Douglas H. Smith, a professor in the Department of Neurosurgery and Director of the Center for Brain Injury and Repair at Penn, says that he and his colleagues have successfully grown, transplanted, and integrated axon bundles that act as "jumper cables" to the host tissue in order to bridge a damaged section of nerve.
This advance attains significance because there are insufficient means for repairing peripheral nerve injuries that, in many cases, result in permanent loss of motor function, sensory function, or both.
Previously, Smith and colleagues have "stretch-grown" axons (nerve fibres) by placing neurons from rat dorsal root ganglia, clusters of nerves just outside the spinal cord, on nutrient-filled plastic plates.
Axons sprouted from the neurons on each plate and connected with neurons on the other plate, which were then slowly pulled apart over a series of days, aided by a precise computer-controlled motor system.
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