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Killer T Cell Treatment Helps Against Cancers in Transplant Patients
August 17, 2007 at 3:23 PM
Cancer News
A team of researchers at the University of Edinburgh generated killer T cells from healthy Scottish blood donors and injected them into patients with a type of blood cell cancer called PTLD. This form of cancer is caused by a virus in transplant patients whose immune systems have been suppressed to stop their new organ from being rejected and affects up to around 10 per cent of transplant patients.
Around two thirds of patients responded to the treatment. If further trials are successful, a single bank of T cells could potentially serve as a global source of immune cells to treat the condition. PTLD is caused by the Epstein-Barr virus, a viral infection that over 90 per cent of adults carry.
Normally the virus causes no ill effects but it can reactivate in transplant patients and cause PTLD. Because children are less likely to have been previously exposed to the virus, they are more prone to develop PTLD when they meet the virus for the first time after transplant.
Lead researcher Dr Tanzina Haque, now at the Royal Free and University College Medical School, London, said: "EBV infection after transplantation carries a high risk of PTLD. Our results are encouraging and show that T cell therapy could present a safe alternative treatment for the disease."
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