Kids with obstructive sleep apnea (OSA) may one day be able to have an injection or use a throat spray instead of getting their tonsils removed to cure their snoring, a new study has found.
The study from the University of Chicago found that a specific gene product might be responsible for the proliferation of adenotonsillar tissue that can cause pediatric OSA.
"We found that in the tonsil tissues of children with OSA, certain genes and gene networks were over expressed," David Gozal, M.D., professor and chair of the Department of Pediatrics, who led the study, said.
"We believe that the results of this gene overexpression is increased proliferation of the adenotonsillar tissues, which in turn can cause partial or complete obstruction of the upper airways during sleep," he stated.
Dr. Gozal and colleagues have been studying potential non-surgical alternatives to treat OSA in children.
To identify potential pharmacological targets, they recruited 18 children with OSA and 18 age-, gender-, and ethnicity-matched children with recurrent tonsillar infections (RI), all of who underwent surgery to have their tonsils removed.